The Computational Physiology Lab (CPL) was founded in 2002 by Dr. Ioannis Pavlidis and since then gained worldwide recognition. At this moment the lab has three research lines and an educational research effort on science ethics. Our focus is on unobtrusive and sustained monitoring of physiological variables. This is embedded imaginatively in psycho-physiological, biomedical, and behavioral paradigms. Sensing is effected either through thermal imaging or wearable transducers. This novel methodological work has spurred psychological and medical discoveries and formed the basis for new applications. Substantial technical sophistication is involved in performing physiological measurements of this kind. Elements from mathematics, computing, statistics, medicine, and physiologiy need to come together. CPL is an interdisciplinary lab and draws additional expertise from partner labs in Mayo Clinic, University of Texas Medical School, Methodist Hospital, and The State University of NewYork (SUNY) at Buffalo. CPL is famous for its work in stress quantification, lie detection, sleep studies, and behavioral gaming. All of them found civilian or military applications. The research of our members has been published in some of the most prestigious science journals and venues, including Nature, Lancet, New England Journal of Medicine, and CHI. We are dedicated to both scientific and engineering excellence and a genuine desire to produce tangible social good.